Converting Solution Macromolecular Thermodynamic Properties into Gas-Phase Mass Spectrometry Observations

Accurate thermodynamic properties of gas phase hydrogen bonded complexes.

We have measured the infrared spectra of ethanol·dimethylamine and methanol·dimethylamine complexes in the 299-374 K temperature range, and have determined the enthalpy of complex formation (ΔH) to be -31.1 ± 2 and -29.5 ± 2 kJ mol(-1), respectively. The corresponding values of the Gibbs free energy (ΔG) are determined from the experimental integrated absorbance and a calculated oscillator stre...

Gas Chromatography - Mass Spectrometry

Gas Chromatography-Mass Spectrometry

Gas chromatography (GC) is a widely applied technique in many branches of science and technology. For over half a century, GC has played a fundamental role in determining how many components and in what proportion they exist in a mixture. However, the ability to establish the nature and chemical structure of these separated and quantified compounds is ambiguous and reduced, and requires a spect...

Gas Chromatography - Mass Spectrometry

High-pressure gas phase femtosecond laser ionization mass spectrometry.

We describe a novel ion source for analytical mass spectrometry based on femtosecond laser ionization at pressures at and above atmospheric and characterize its performance when coupled to a tandem quadrupole/time-of-flight mass spectrometer. We assess source saturation limits, ionization and sampling efficiencies, the effective ionization volume, and limits of detection. We demonstrate 100% ef...